Jens Wrammert

This study compares antibody responses in infants after influenza infection or vaccination, finding greater post-exposure responses following infection compared to vaccination.

This study evaluates antibody responses after a KP.2 spike mRNA vaccine dose, showing durable and broadly cross-reactive immunity against multiple SARS-CoV-2 variants, but reduced neutralizing activity against some emerging subvariants.

This study shows that antigenic selection of influenza virus within hosts is driven by immune pressure timing and fitness tradeoffs, with moderate stochastic effects observed.

This paper develops a high-throughput method to identify and characterize neutralizing antibodies in vaccinated rhesus macaques, revealing key features of effective antibody responses.

This study shows that dirty mice, with broad microbial exposure, better model human immune responses to SARS-CoV-2 mRNA vaccines, showing reduced antibody titers and faster waning compared to SPF mice.

This study identifies an IgG3 subclass antibody that expands neutralization breadth against dengue and zika viruses by engaging a quaternary epitope through structural and functional analyses.

This study identifies FcγRI as the critical Fc receptor mediating antibody-enhanced ZIKV infection of placental macrophages through genetic and functional analyses.

The paper evaluates the effectiveness of an XBB.1.5 monovalent booster vaccine, showing improved antibody binding and neutralization against SARS-CoV-2 Omicron variants.