Renal nutrient loss promotes metabolic health at the expense of increased vulnerability to acute kidney injury
Harry B. Cutler, Diaz-Vegas Alexis, Oliver K Fuller, Kristen C. Cooke, Stewart W. C. Masson, Søren Madsen, Jacqueline Stöckli, Sanae Ashitani, Kaori Igarashi, Tomoyoshi Soga, Liang Gao, Federico Tesio Torta, David Ernest James
This study identifies a renometabolic trade-off where increased urinary nutrient loss protects against obesity but increases vulnerability to acute kidney injury.
bioRxiv · Sep 29, 2026 · PreprintPhysiology