Søren Madsen

This study identifies a renometabolic trade-off where increased urinary nutrient loss protects against obesity but increases vulnerability to acute kidney injury.

Synteny prioritizes disease-relevant genes and identifies functionally important proteins using human genetic evidence.

This study identifies a genetic locus affecting insulin sensitivity in mice, showing that Defa26 modulates glucose homeostasis through microbiome interactions.

This study identifies SEC61B as a regulator of calcium flux and platelet hyperreactivity in diabetes by linking ER stress to increased SEC61B expression and calcium leak.

The paper identifies very long-chain ceramides in muscle as independently associated with insulin resistance, separate from adiposity effects, using genetic variation in mice.

This study uses phosphoproteomics to show how genetic background and diet influence insulin signalling in muscle, revealing key regulators of insulin responsiveness and glycolysis in insulin resistance.

The paper identifies small molecules that reverse insulin resistance in mouse skeletal muscle by integrating systems genetics and chemical screening.

This study uses phosphoproteomics to show that insulin resistance involves rewired signaling networks and widespread dysregulation of GSK3 activity.

The paper compares proteomics profiles of subcutaneous and visceral adipose tissue in mice to identify depot-specific differences and responses to diet.