Stewart W. C. Masson

This study identifies a renometabolic trade-off where increased urinary nutrient loss protects against obesity but increases vulnerability to acute kidney injury.

Synteny prioritizes disease-relevant genes and identifies functionally important proteins using human genetic evidence.

This study identifies a genetic locus affecting insulin sensitivity in mice, showing that Defa26 modulates glucose homeostasis through microbiome interactions.

The paper identifies very long-chain ceramides in muscle as independently associated with insulin resistance, separate from adiposity effects, using genetic variation in mice.

This study uses phosphoproteomics to show how genetic background and diet influence insulin signalling in muscle, revealing key regulators of insulin responsiveness and glycolysis in insulin resistance.

The paper identifies small molecules that reverse insulin resistance in mouse skeletal muscle by integrating systems genetics and chemical screening.