Harry B. Cutler

Renal nutrient loss promotes metabolic health at the expense of increased vulnerability to acute kidney injury

This study identifies a renometabolic trade-off where increased urinary nutrient loss protects against obesity but increases vulnerability to acute kidney injury.

Systems genetics identifies ETS1 as a stress-dependent regulator of adipocyte insulin action and heme-iron homeostasis

Synteny: a high throughput web tool to streamline causal gene prioritisation and provide insight into protein function

Synteny prioritizes disease-relevant genes and identifies functionally important proteins using human genetic evidence.

Genetic variance in the murine defensin locus modulates glucose homeostasis

This study identifies a genetic locus affecting insulin sensitivity in mice, showing that Defa26 modulates glucose homeostasis through microbiome interactions.

Very long-chain ceramides in muscle associate with insulin resistance independent of obesity

The paper identifies very long-chain ceramides in muscle as independently associated with insulin resistance, separate from adiposity effects, using genetic variation in mice.

The genetic and dietary landscape of the muscle insulin signalling network

This study uses phosphoproteomics to show how genetic background and diet influence insulin signalling in muscle, revealing key regulators of insulin responsiveness and glycolysis in insulin resistance.

Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance

The paper identifies small molecules that reverse insulin resistance in mouse skeletal muscle by integrating systems genetics and chemical screening.