A human induced pluripotent stem cell-based high-throughput screening platform for teratogenicity hazard identification
Henrik Renner, Kinga Maria Wrona, Christopher Bruhn, Alice Drobny, Rachel McCannon, Fabrizia Zoppetti, Meik Henningsen, Kornelia Kuc, Carsten Jörn Beese, Carina Wollnik, Vladimir Galatenko, Alexandra Hackmann, Sandra Lubitz, Bastian Zimmer
Four-model hiPSC screen in 384-well imaging reached 83% accuracy (88% sensitivity, 75% specificity) on 130 scored compounds from a 146-compound reference set, scalable to hundreds of compounds monthly.
bioRxiv · Oct 30, 2026 · PreprintPharmacology & Toxicology✦ In-depth digest