Sandra Minotti

Localized synthesis of molecular chaperones sustains neuronal proteostasis

The paper shows that neuronal stress response involves localized synthesis of HSPA8 mRNA in dendrites to maintain proteostasis and prevent neurodegeneration.

CK1α, FAM83H, and FAM83B contribute to bundling of neurofilaments and are sequestered in cellular and mice models of ARSACS

The paper identifies CK1α, FAM83H, and FAM83B as contributors to neurofilament bundling in ARSACS and shows their upregulation and co-localization in affected cells.

Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS

This study examines the effects of HDAC inhibitors and arimoclomol on HSP expression and disease biomarkers in ALS models, finding variable responses across different ALS variants and biomarkers.