Aggressive Cholesterol Lowering Normalizes Atherosclerosis Regression in Jak2V617F Mice
Brian D. Hardaway, Trevor P. Fidler, Mojdeh S. Tavallaie, Cheng-Chieh Hsu, Sandra Schiavone, Tong Xiao, Ranran Wang, Nan Wang, Alan R. Tall
This study shows that aggressive cholesterol lowering halts atherosclerosis progression and promotes plaque stabilization in Jak2V617F mice by reversing inflammasome activation and increasing pro-resolving macrophage features.
Journal of Lipid Research · Feb 18, 2026Peer-reviewedMolecular Biology