Tong Xiao

This study shows TREM2 agonism in clonal hematopoiesis enhances fibrous cap formation via macrophage-derived PDGFB and stromal PDGFR? signaling, increasing specific fibroblast populations and reducing macrophage migration.

This study shows that aggressive cholesterol lowering halts atherosclerosis progression and promotes plaque stabilization in Jak2V617F mice by reversing inflammasome activation and increasing pro-resolving macrophage features.

This study shows that IL-18 inhibition increases atherosclerosis lesions and necrotic cores in Jak2V617F clonal hematopoiesis mice, despite improving fibrous cap thickness.