Author

Cheng-Chieh Hsu

Columbia University Irving Medical CenterORCID 0000-0002-3423-7159Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Alan R. TalliD· 2 shared Brian D. HardawayiD· 2 shared Mojdeh S. TavallaieiD· 2 shared Nan WangiD· 2 shared Tong XiaoiD· 2 shared Trevor P. FidleriD· 2 shared David NgaiiD· 1 shared Eunyoung KimiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Alan R. TallORCID

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2 papers

Recent·Most cited

Aggressive Cholesterol Lowering Normalizes Atherosclerosis Regression in Jak2V617F Mice

Brian D. Hardaway, Trevor P. Fidler, Mojdeh S. Tavallaie, Cheng-Chieh Hsu, Sandra Schiavone, Tong Xiao, Ranran Wang, Nan Wang, Alan R. Tall

This study shows that aggressive cholesterol lowering halts atherosclerosis progression and promotes plaque stabilization in Jak2V617F mice by reversing inflammasome activation and increasing pro-resolving macrophage features.

Journal of Lipid Research · Feb 18, 2026Peer-reviewedMolecular Biology

IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2V617F clonal hematopoiesis-driven atherosclerosis.

Mojdeh S. Tavallaie, Cheng-Chieh Hsu, Brian D. Hardaway, Huijuan Dou, Trevor P. Fidler, Eunyoung Kim, Sandra Abramowicz, David Ngai, Tong Xiao, Nan Wang, Marit Westerterp, Alan R. Tall

This study shows that IL-18 inhibition increases atherosclerosis lesions and necrotic cores in Jak2V617F clonal hematopoiesis mice, despite improving fibrous cap thickness.

bioRxiv · Jun 3, 2025 · PreprintMolecular Biology