Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A-mutated cancers
Jae‐Joong Kim, Jaeik Oh, D G Jang, Seungjae Shin, Soo-Jin Lee, Sang Eun Lee, Yoojin Yang, Dohee Kim, Ae Jin Choi, Hae Rim Jung, Yumi Oh, Sung‐Yup Cho
This study identifies WRN as a therapeutic target in ARID1A-mutated cancers, showing that its inhibition causes DNA damage and cell death, with potential for combination therapy with p21 inhibition.
Science Advances · Jun 5, 2026Peer-reviewedCancer Biology