Disruption of the KH1 domain of Fmr1 leads to transcriptional alterations and attentional deficits in rats
Carla E. M. Golden, Michael S. Breen, Lacin Koro, Sankalp Sonar, Kristi Niblo, Andrew Browne, Natalie Burlant, Daniele Di Marino, Silvia De Rubeis, Mark G. Baxter, Joseph D. Buxbaum, Hala Harony‐Nicolas
This study shows that deleting the KH1 domain of Fmr1 in rats causes attention deficits and transcriptional changes in the medial prefrontal cortex, similar to FXS, and identifies potential therapeutic targets.
Cerebral Cortex · Feb 6, 2019Peer-reviewedNeuroscience