Author

Andrew Browne

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Organism:human· 4 Research Focus:gene regulatory network inference· 3 Research Focus:eQTL / molecular QTL mapping· 1 Organism:rat· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Joseph D. BuxbaumiD· 4 shared Michael S. BreeniD· 4 shared Gabriel E. HoffmaniD· 3 shared Kristen BrennandiD· 3 shared Panos RoussosiD· 3 shared Robin KrameriD· 3 shared Alexander W. CharneyiD· 2 shared Amanda L. DobbyniD· 2 shared

Activity by Year

2016-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Joseph D. BuxbaumORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Solveig K. Sieberts, Thanneer Malai Perumal, Minerva M. Carrasquillo, Mariet Allen, Joseph S. Reddy, Gabriel E. Hoffman, Kristen K. Dang, John N. Calley, Philip J. Ebert, James A. Eddy, Xue Wang, Anna K. Greenwood, Sara Mostafavi, Schahram Akbarian, Jaroslav M. Bendl, , Chris Gaiteri

This paper performs a large-scale eQTL meta-analysis across cerebral cortical and cerebellar brain regions, identifying distinct eQTL patterns and demonstrating improved power over existing studies.

Scientific Data · Oct 12, 2020Peer-reviewedGenetics

Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan McDermid syndrome and autism

Michael S. Breen, Andrew Browne, Gabriel E. Hoffman, Sofia Stathopoulos, Kristen Brennand, Joseph D. Buxbaum, Elodie Drapeau

The paper uses hiPSC-derived neural cells from PMS patients and siblings to identify transcriptional changes, finding altered Wnt signaling and shared ASD-related genes.

Molecular Autism · Jun 19, 2020Peer-reviewedNeuroscience

Functional annotation of rare structural variation in the human brain

Lide Han, Xuefang Zhao, Mary Lauren Benton, Thanneer Malai Perumal, Ryan L. Collins, Gabriel E. Hoffman, Jessica Johnson, Laura Gail Sloofman, Harold Z. Wang, Matthew R. Stone, Schahram Akbarian, Jaroslav M. Bendl, Michael S. Breen, Kristen Brennand, Leanne Brown, , Michael E. Talkowski

The paper functionally annotates rare structural variants in the human brain by integrating SV calling with RNA-seq data to assess their regulatory effects and prioritize pathogenic deletions.

Nature Communications · Jun 12, 2020Peer-reviewedGenomics

Disruption of the KH1 domain of Fmr1 leads to transcriptional alterations and attentional deficits in rats

Carla E. M. Golden, Michael S. Breen, Lacin Koro, Sankalp Sonar, Kristi Niblo, Andrew Browne, Natalie Burlant, Daniele Di Marino, Silvia De Rubeis, Mark G. Baxter, Joseph D. Buxbaum, Hala Harony‐Nicolas

This study shows that deleting the KH1 domain of Fmr1 in rats causes attention deficits and transcriptional changes in the medial prefrontal cortex, similar to FXS, and identifies potential therapeutic targets.

Cerebral Cortex · Feb 6, 2019Peer-reviewedNeuroscience

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

Menachem Fromer, Panos Roussos, Solveig K Sieberts, Jessica S Johnson, David H Kavanagh, Thanneer M Perumal, Douglas M Ruderfer, Edwin C Oh, Aaron Topol, Hardik R Shah, Lambertus L Klei, Robin Kramer, Dalila Pinto, Zeynep H Gumus, A. Ercument Cicek, , Lara M Mangravit

The paper uses gene expression data from schizophrenia cases and controls to show that common variants at 20% of schizophrenia risk loci regulate brain gene expression, with functional impacts on neural progenitor cells and zebrafish neuroanatomy.

bioRxiv · May 9, 2016Genomics