Mark G. Baxter

This study creates normative brain growth charts for rhesus macaques across their lifespan using MRI data, revealing developmental milestones and cross-species comparisons with humans.

This study shows that the hippocampus represents goals based on their temporal distance, with current goals in the posterior and temporally removed goals in the anterior.

The paper integrates multi-omics data from female baboons to identify age-related molecular changes in the prefrontal cortex, revealing altered signaling pathways and potential biomarkers for age-related cognitive decline.

This study investigates the development of prefrontal corticostriatal connectivity in mice, showing that axons target their zones early and synapses do not undergo extensive pruning, with Cdh8 playing a role in behavioral outcomes.

This study compares cognitive performance between young and aged rhesus monkeys on three tasks, finding age-related declines and task-specific independence in cognitive aging.

This study shows that early-life sevoflurane exposure in rhesus monkeys leads to long-term synaptic ultrastructural changes in the hippocampus and prefrontal cortex.

This study shows that LRRK2-G2019S mutation in mice causes cognitive deficits and reduced cholinergic innervation in brain regions linked to executive function.

This study identifies a mechanism where hippocampal ensembles are remodeled to support memory-updating in mice during spatial reversal tasks.

The paper reevaluates the efficacy of nonhuman primate optogenetics for psychiatry, finding lower success rates when applying more relevant criteria to human neuropsychiatric disease.

This study tests the effects of three DREADD actuator drugs on working memory in rhesus monkeys, finding dose-dependent impairments in some monkeys.

The paper examines resting state functional connectivity changes in older adults during post-anesthesia recovery, finding reduced anticorrelations one hour post-anesthesia that return to baseline after one day.

This study shows that deleting the KH1 domain of Fmr1 in rats causes attention deficits and transcriptional changes in the medial prefrontal cortex, similar to FXS, and identifies potential therapeutic targets.

The paper identifies a theta band network in the prefrontal and temporal lobes that is uniquely activated during episodic memory tasks in humans.

This study shows that chemogenetic inhibition in rhesus monkeys affects behavior based on the level of receptor transduction, with higher transduction linked to greater behavioral impairment.

This study shows that hippocampal lesions in rhesus monkeys impair scene memory retrieval but not new learning, suggesting the hippocampus is critical for recalling past memories but not forming new ones.

This study shows that starting estradiol treatment more than 2 years after menopause in aged rhesus monkeys improves cognitive function, while stopping treatment later does not reduce cognitive benefits.

This study investigates the effects of Aβ oligomers on synaptic pathology and neuroinflammation in a female rhesus monkey model of Alzheimer’s disease, finding significant synaptic loss and inflammatory responses.

The paper introduces PRIME-DE, an open resource for non-human primate MRI data, aggregating 13 datasets from 11 sites across 98 macaques.

This study finds no sex differences in higher cognitive function between male and female rhesus monkeys in episodic memory and strategy implementation tests.