Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models
Seiko Ikezu, Kaitlin L. Ingraham Dixie, Lacin Koro, Takashi Watanabe, Kozo Kaibuchi, Tsuneya Ikezu
This study shows that TTBK1 and Aβ synergistically induce CRMP2 phosphorylation, leading to neurite degeneration and pTau accumulation in AD mouse models.
Acta Neuropathologica Communications · Feb 4, 2020Peer-reviewedNeuroscience