Author

Sankar Sundaram

Government Medical College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

Chenicheri Kizhakkeveettil KeerthanaiD· 3 shared Kalimuthu Kalishwaralal· 3 shared Kuzhuvelil B. HarikumariD· 3 shared Lekshmi R. NathiD· 3 shared Mundanattu SwethaiD· 3 shared Nikhil Ponnoor AntoiD· 3 shared Noah IsakoviD· 3 shared Ravi Shankar LankalapalliiD· 3 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Chenicheri Kizhakkeveettil KeerthanaORCID

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3 papers

Recent·Most cited

Uttroside B, a US FDA-designated Orphan drug, mitigates thedevelopment of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3

Chenicheri Kizhakkeveettil Keerthana, Tennyson Prakash Rayginia, Kalimuthu Kalishwaralal, Sandhini Saha, Nair Hariprasad Haritha, Amrutha Nisthul A., Mundanattu Swetha, Sreekumar Usha Devi Aiswarya, Lekshmi R. Nath, Sanjay Suresh Varma, Arun (Geetha) Viswanathan, Somaraj Jannet, Shirly J, Jayasekharan S. Aparna, Archana Praveen, , Ruby John Anto

This study shows that Uttroside B inhibits hepatocellular carcinoma and its pulmonary metastasis by blocking the EGFR/ERK pathway and its downstream targets SREBP-1 and STAT-3.

Cell Death Discovery · Apr 16, 2026Peer-reviewedCancer Biology

Evaluating the therapeutic efficacy of the US FDA-designated Orphan drug, uttroside B in impeding hepatocarcinogenesis via induction of immunogenic apoptosis, using a murine model of Aflatoxin B1-induced liver carcinogenesis

Mundanattu Swetha, Chenicheri Kizhakkeveettil Keerthana, Tennyson Prakash Rayginia, Kalimuthu Kalishwaralal, Sadiq Chembothumparambil Shifana, Sreekumar Usha Devi Aiswarya, Lekshmi R. Nath, Sanjay Suresh Varma, Arun (Geetha) Viswanathan, Somaraj Jannet, J Shirly, Jayasekharan S. Aparna, Sankar Sundaram, Nikhil Ponnoor Anto, Noah Isakov, , Ruby John Anto

This study evaluates uttroside B's efficacy in preventing AFB1-induced hepatocarcinogenesis in mice by inducing immunogenic apoptosis and blocking immune checkpoints.

bioRxiv · Sep 8, 2025 · PreprintCancer Biology

Uttroside B, a US-FDA-Designated Orphan Drug Against Hepatocellular Carcinoma (HCC), Impedes Non-alcoholic Steatohepatitis (NASH) and NASH -Induced HCC

Tennyson Prakash Rayginia, Chenicheri Kizhakkeveettil Keerthana, Sreekumar Usha Devi Aiswarya, Sadiq Chembothumparambil Shifana, Somaraj Jannet, Sanjay Suresh Varma, Joy P Maria, Mundanattu Swetha, Archana Payickattu Retnakumari, Lekshmi R. Nath, Kalimuthu Kalishwaralal, Vishnu Sunil Jaikumar, Sankar Sundaram, Nikhil Ponnoor Anto, Noah Isakov, , Ruby John Anto

This study demonstrates that Uttroside B alleviates NASH and prevents its progression to HCC in mouse models.

bioRxiv · Nov 6, 2024 · PreprintCancer Biology