Nikhil Ponnoor Anto

This study shows that Uttroside B inhibits hepatocellular carcinoma and its pulmonary metastasis by blocking the EGFR/ERK pathway and its downstream targets SREBP-1 and STAT-3.

This study evaluates uttroside B's efficacy in preventing AFB1-induced hepatocarcinogenesis in mice by inducing immunogenic apoptosis and blocking immune checkpoints.

This study shows GSK-3 enhances PD-1 blockade by promoting CD4-CD8 T-cell cooperation, leading to more effective anti-tumor CD8+ cytolytic T cells.

This study demonstrates that Uttroside B alleviates NASH and prevents its progression to HCC in mouse models.

This study shows that PD-1 internalization enhances the cytolytic potential of checkpoint blockade by removing PD-1 from T-cells, improving anti-tumor immunity.