Open-ended molecular recording of sequential cellular events into DNA
Theresa B. Loveless, Courtney K. Carlson, Catalina A. Dentzel Helmy, Vincent J. Hu, Sara K. Ross, Matt C. Demelo, Ali Murtaza, Guohao Liang, Michelle Ficht, Arushi Singhai, Marcello Pajoh-Casco, Chang C. Liu
This paper introduces peCHYRON, a DNA recorder that sequentially records cellular events in mammalian cells using prime editing, enabling durable, high-information, and temporally resolved molecular recording.
Nature Chemical Biology · Nov 14, 2024Peer-reviewedGenetics