An ALK1-governed monocytic lineage shapes an immunosuppressive landscape inbreast cancer metastases
Mehrnaz Safaee Talkhoncheh, Jonas Sjölund, Paulina Bolívar, Ewa Kurzejamska, Eugenia Cordero, Teia Vallès Pagès, Sara Larsson, Sophie Lehn, Gustav Frimannsson, Viktor Ingesson, Sebastian Benedict Braun, Jessica Pantaleo, Clara Oudenaarden, Martin Lauss, Robert Scott Pearsall, , Kristian Pietras
The paper identifies ALK1-expressing tumor-associated macrophages in breast cancer metastases that contribute to immunosuppression and poor patient survival.
Journal of Clinical Investigation · Jan 14, 2025Peer-reviewedCancer Biology