Kristian Pietras

This paper uses mathematical modeling to show that targeting cancer-associated fibroblasts can improve treatment efficacy for ER+ breast cancer across different estrogen dosing regimens.

This study repurposes statins and phenothiazines to treat chemoresistant neuroblastoma, showing synergistic effects and improved survival in preclinical models.

The paper maps transcriptional changes in astrocyte and tumor cell states during glioblastoma progression and recurrence, identifying reactive astrocyte-like tumor cells associated with radioresistance.

This study identifies pericytes as a key paracrine signaling hub in glioblastoma that restrains tumor progression by modulating the tumor microenvironment and immune response.

The paper identifies ALK1-expressing tumor-associated macrophages in breast cancer metastases that contribute to immunosuppression and poor patient survival.

This study identifies hypoxia-induced complement component 3 (C3) as a driver of aggressive glioblastoma growth by promoting cell proliferation and radio-resistance.