Goran B Jönsson

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as modulating risk for melanoma and nevi via RAS activation

This study identifies RAPGEF1 as a gene modulating melanoma and nevi risk through RAS activation, using fine-mapping, expression data, and functional assays.

Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrence

The paper maps transcriptional changes in astrocyte and tumor cell states during glioblastoma progression and recurrence, identifying reactive astrocyte-like tumor cells associated with radioresistance.

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma

This study identifies pericytes as a key paracrine signaling hub in glioblastoma that restrains tumor progression by modulating the tumor microenvironment and immune response.

An ALK1-governed monocytic lineage shapes an immunosuppressive landscape inbreast cancer metastases

The paper identifies ALK1-expressing tumor-associated macrophages in breast cancer metastases that contribute to immunosuppression and poor patient survival.

Tumour gene expression signature in primary melanoma predicts long-term outcomes: A prospective multicentre study

This paper develops a gene expression signature, Cam_121, to predict long-term outcomes in primary melanoma patients, showing improved accuracy compared to clinical and existing prognostic models.