Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes
Ana Janeva, Christopher A. Penfold, Sara Llorente-Armijo, Huiwen Li, Tomáš Zikmund, Marco Stock, Jérôme Jullien, Tobias Straub, Ignasi Forné, Axel Imhof, Juan M. Vaquerizas, John Bertrand Gurdon, Eva Hörmanseder
This study identifies H3K27ac as an epigenetic barrier to reprogramming-induced cell fate changes using an AI-based approach and shows that reducing H3K27ac improves reprogramming efficiency.
bioRxiv · Jan 22, 2025 · PreprintGenomics