Christopher A. Penfold

This study identifies H3K27ac as an epigenetic barrier to reprogramming-induced cell fate changes using an AI-based approach and shows that reducing H3K27ac improves reprogramming efficiency.

This study generates marmoset PGCLCs from iPSCs using mRNA transfection and shows their differentiation into gonocyte-like cells in xenoreconstituted testes.

The paper investigates human primordial germ cell specification using in vitro models and in vivo datasets, revealing the role of TFAP2A and TFAP2C in PGC fate and amnion development.

This study maps in vitro megakaryocyte progenitor states to their in vivo counterparts and identifies surface markers for their purification.

This paper develops a Bayesian framework for analyzing non-stationary semiflexible polymers using ensembles of trajectories, showing improved performance on yeast chromosome data.

This paper develops a Bayesian pseudotime method to model transcriptional branching in human embryos and identifies regulators of PGC specification.

This paper introduces branch-recombinant Gaussian processes (B-RGPs) to analyze branching and recombination in biological time series, demonstrating their application to gene expression data in Arabidopsis thaliana.