Unbiased identification of nanoparticle cell uptake mechanism via a genome-wide CRISPR/Cas9 knockout screen
Eric L. Van Nostrand, Sarah A. Barnhill, Alexander A. Shishkin, David A. Nelles, Eric Byeon, Thai B. Nguyen, Yiu Chueng Eric Wong, Nathan C. Gianneschi, Gene Wei-Ming Yeo
The paper uses a genome-wide CRISPR/Cas9 knockout screen to identify novel transporters involved in nanoparticle uptake, finding SLC18B1 mediates polymeric micellar nanoparticle uptake.
bioRxiv · Oct 8, 2020 · PreprintGenomics