Thai B. Nguyen

This study identifies TDP-43 dysfunction and reduced m6A modification as mechanisms causing aberrant splicing in Huntington's disease using mouse and human brain data.

The paper uses a genome-wide CRISPR/Cas9 knockout screen to identify novel transporters involved in nanoparticle uptake, finding SLC18B1 mediates polymeric micellar nanoparticle uptake.

The paper maps and characterizes RNA elements recognized by human RNA binding proteins in K562 and HepG2 cells, expanding the catalog of functional elements in the human genome.

The paper analyzes eCLIP data for 150 RBPs in K562 and HepG2 cells, revealing binding modalities, RBP functions, and novel RNA processing mechanisms.

This study identifies widespread hypo-editing in ASD brains and links RNA editing dysregulation to Fragile X syndrome through FMRP/FXR1P-ADAR interactions.