Author

David A. Nelles

University of California San DiegoORCID 0000-0003-0711-8864Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Gene Wei-Ming YeoiD· 2 shared Alexander A. Shishkin· 1 shared Eric Byeon· 1 shared Eric L. Van NostrandiD· 1 shared Florian KrachiD· 1 shared James D. ThomasiD· 1 shared Lukasz Snjader· 1 shared Maurice S. SwansoniD· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Gene Wei-Ming YeoORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 8, 2020

Unbiased identification of nanoparticle cell uptake mechanism via a genome-wide CRISPR/Cas9 knockout screen

Eric L. Van Nostrand, Sarah A. Barnhill, Alexander A. Shishkin…·Gene Wei-Ming Yeo

The paper uses a genome-wide CRISPR/Cas9 knockout screen to identify novel transporters involved in nanoparticle uptake, finding SLC18B1 mediates polymeric micellar nanoparticle uptake.

1 citation

experimental assayperturbation response prediction

𝕏 PostBluesky

Molecular BiologybioRxivPreprintSep 4, 2017

Reversal of molecular pathology by RNA-targeting Cas9 in a myotonic dystrophy mouse model

Ranjan Batra, David A. Nelles, Florian Krach…·Gene Wei-Ming Yeo

RNA-targeting Cas9 reverses molecular pathology in a myotonic dystrophy mouse model by eliminating toxic CUG RNA and restoring normal cellular functions.

4 citations

mouseexperimental assay

𝕏 PostBluesky