Author

Sarah Benedetto

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Giulia Di MuzioiD· 2 shared Jana BerlandaiD· 2 shared Nina Claudino· 2 shared Pei‐Chi WeiiD· 2 shared Thomas HöferiD· 2 shared Alex IngiD· 1 shared Anna J. M. MarxiD· 1 shared Boyu DingiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Giulia Di MuzioORCID

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2 papers

Recent·Most cited

Recurrent DNA Break Clusters Regulated by Polymerase Theta Are Essential for Replication Stress Induced Copy Number Variation

Lorenzo Corazzi, Alex Ing, Vivien S. Ionasz, Anna J. M. Marx, Nathan Trausch, Sarah Benedetto, Giulia Di Muzio, Boyu Ding, Jana Berlanda, Marco Giaisi, Nina Claudino, Thomas Höfer, Pei‐Chi Wei

This study identifies recurrent DNA break clusters (RDCs) as causal factors for CNV formation under replication stress and shows DNA polymerase theta's role in preventing these events.

bioRxiv · Sep 1, 2025 · PreprintMolecular Biology

Adaptive Clonal Expansion Shapes Brain Development

Giulia Di Muzio, Sarah Benedetto, Li-Chin Wang, Lea Weber, Franciscus van der Hoeven, Brittney Armstrong, Hsin-Jui Lu, Jana Berlanda, Verena Körber, Nina Claudino, Michelle Krogemann, Thomas Höfer, Pei‐Chi Wei

The paper investigates NSPC proliferation dynamics in a mouse model, finding that adaptive clonal expansion by a small fraction of NSPCs can regenerate the entire neuronal population.

bioRxiv · Mar 4, 2025 · PreprintDevelopmental Biology