Giulia Di Muzio

Recurrent DNA Break Clusters Regulated by Polymerase Theta Are Essential for Replication Stress Induced Copy Number Variation

This study identifies recurrent DNA break clusters (RDCs) as causal factors for CNV formation under replication stress and shows DNA polymerase theta's role in preventing these events.

Adaptive Clonal Expansion Shapes Brain Development

The paper investigates NSPC proliferation dynamics in a mouse model, finding that adaptive clonal expansion by a small fraction of NSPCs can regenerate the entire neuronal population.

Linear Interaction Between Replication and Transcription Shapes DNA Break Dynamics at Recurrent DNA Break Clusters

The paper investigates DNA break dynamics at recurrent DNA break clusters (RDCs) in mouse neural progenitor cells, revealing how replication-transcription collisions influence DSB formation and orientation.