A Sequential Triple-Drug Strategy for Selective Targeting of p53-Mutant Cancers
Mohammed Alruwaili, Yanqi Guo, Justin Zonneville, Thomas Melendy, Robert M. Straubinger, Barbara A. Foster, Priyanka Rajan, Henry G. Withers, Sarah Chatley, Renuka V. Iyer, Christos K Fountzilas, Andrei V. Bakin
This paper develops a sequential triple-drug strategy targeting p53 mutant cancers, showing it effectively induces cell death while minimizing toxicity to normal cells.
bioRxiv · Nov 6, 2025 · PreprintCancer Biology