Author

Henry G. Withers

Roswell Park Comprehensive Cancer CenterORCID 0000-0002-9746-9352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Abdul Saboor KhaniD· 1 shared Andrei V. BakiniD· 1 shared Barbara A. FosteriD· 1 shared Brian Buckley· 1 shared Christos K FountzilasiD· 1 shared Joyce Ellen OhmiD· 1 shared Justin ZonnevilleiD· 1 shared Katerina I. LeonovaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

Abdul Saboor KhanORCID

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3 papers

Recent·Most cited

Multidirectional Cellular Plasticity in Ewing Sarcoma Reveals a Tumor-CAF Continuum and Novel Immunotherapeutic Targets

Mohamed A. Sharif, Abdul Saboor Khan, Renier J. Brentjens, Scott H. Olejniczak, Henry G. Withers, Joyce Ellen Ohm

This study identifies a tumor-CAF continuum in Ewing sarcoma through single-cell RNA sequencing, revealing novel surface antigens as potential immunotherapeutic targets.

bioRxiv · Aug 4, 2026 · PreprintCancer Biology

A Sequential Triple-Drug Strategy for Selective Targeting of p53-Mutant Cancers

Mohammed Alruwaili, Yanqi Guo, Justin Zonneville, Thomas Melendy, Robert M. Straubinger, Barbara A. Foster, Priyanka Rajan, Henry G. Withers, Sarah Chatley, Renuka V. Iyer, Christos K Fountzilas, Andrei V. Bakin

This paper develops a sequential triple-drug strategy targeting p53 mutant cancers, showing it effectively induces cell death while minimizing toxicity to normal cells.

bioRxiv · Nov 6, 2025 · PreprintCancer Biology

Image-Based Quantitative Single-Cell Method Suggests Increase of Global Chromatin Accessibility in Tumor Compared to Normal Cells lines

Mairead Commane, Vidula Jadhav, Katerina I. Leonova, Brian Buckley, Henry G. Withers, Katerina V. Gurova

The paper introduces an image-based method to measure chromatin accessibility using DNA-binding fluorescent molecules and finds higher accessibility in tumor compared to normal cells.

iScience · Sep 17, 2025Peer-reviewedCancer Biology