Characterization of expression elements for an AAV delivered antibody in nonhuman primates when co-delivered with PD-L1
I. Leguizamo, Abubakarr A. Koroma, Michael Kuipa, Natalie S. Correa, Yash Barot, Sarah D. Hernandez, Meher Sethi, Anushka Das, Jun Xie, Guangping Gao, Stacey Weissman, Casey Whitehead, Stephanie Ehnert, Jennifer S. Wood, Priya Dhole, Matthew R. Gardner
This study evaluates AAV transgene cassettes for expressing 10-1074 antibody in nonhuman primates and mice, showing promoter and WPRE effects on expression levels and immune responses.
bioRxiv · May 30, 2026 · PreprintMicrobiology