Jun Xie

This study shows that co-delivering PD-L1 with an AAV-expressed HIV-1 bNAb reduces anti-drug antibodies and improves bNAb expression and protection against HIV in rhesus macaques.

This study shows that co-delivering PD-L1 with AAV-delivered bNAb 10-1074 reduces ADA responses and improves bNAb durability in rhesus macaques.

This study evaluates AAV transgene cassettes for expressing 10-1074 antibody in nonhuman primates and mice, showing promoter and WPRE effects on expression levels and immune responses.

AAV-delivered broadly neutralizing antibodies provide durable protection against SIV challenge in rhesus macaques, while ADCC-only antibodies do not.

This study shows seipin is essential for recruiting Perilipin-1 to lipid droplets in human adipocytes, maintaining adipocyte identity and preventing de-differentiation.

This paper develops a customized CRISPR-Cas9 base editor to correct the ACTA2 R179H mutation in a mouse model of MSMDS, improving survival and rescuing vascular and neurological phenotypes.

This paper engineers Nme2Cas9 base editors to improve activity and targeting scope, enabling correction of MECP2 mutations with minimal off-target effects.

This study demonstrates the use of protecting oligos to enhance crRNA stability and potency for in vivo genome editing via AAV co-delivery in mice.

This study develops a compact adenine base editor (Nme2-ABE) that can be delivered via a single AAV vector to efficiently edit mouse genomic loci and revert disease mutations in a tyrosinemia model.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

This study shows that combining AAV gene therapy with deoxynucleoside supplementation improves survival and mitochondrial function in Tk2-deficient mice.