Lipid Nanoparticles with Aptamers Enable Targeted mRNA Delivery to CD4⁺ T Cells
Shrey Shah, Meenakshi Ranasinghe, John Decker, Keith Fraser, Ying Wang, Sarah Kinlaw, Morgan Barker, Sawan Patel, Adam Friedman, Sherwood Yao
This paper develops aptamer-functionalized lipid nanoparticles for targeted mRNA delivery to CD4+ T cells, showing enhanced in vitro transfection and in vivo tissue enrichment with safety profiles.
Drug Delivery · Feb 27, 2026Peer-reviewedMolecular Biology