Sawan Patel

This paper develops aptamer-functionalized lipid nanoparticles for targeted mRNA delivery to CD4+ T cells, showing enhanced in vitro transfection and in vivo tissue enrichment with safety profiles.

AptaBLE is a deep learning framework that predicts aptamer-protein binding and generates novel aptamers with high specificity and low Kd values.

EvoFlow-RNA generates and represents non-coding RNA using a masked discrete diffusion model, outperforming existing models on RNA function tasks.