Author

Sherwood Yao

ORCID 0000-0002-2409-289XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Sawan PateliD· 3 shared Fred Zhangzhi Peng· 2 shared Keith FraseriD· 2 shared Pranam ChatterjeeiD· 2 shared Abhisek DwivedyiD· 1 shared Adam D. FriedmaniD· 1 shared Adam Friedman· 1 shared Dhanush GandavadiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Sawan PatelORCID

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3 papers

Recent·Most cited

Lipid Nanoparticles with Aptamers Enable Targeted mRNA Delivery to CD4⁺ T Cells

Shrey Shah, Meenakshi Ranasinghe, John Decker, Keith Fraser, Ying Wang, Sarah Kinlaw, Morgan Barker, Sawan Patel, Adam Friedman, Sherwood Yao

This paper develops aptamer-functionalized lipid nanoparticles for targeted mRNA delivery to CD4+ T cells, showing enhanced in vitro transfection and in vivo tissue enrichment with safety profiles.

Drug Delivery · Feb 27, 2026Peer-reviewedMolecular Biology

AptaBLE: A Deep Learning Platform for Aptamer Generation and Analysis

Sawan Patel, Keith Fraser, Dhanush Gandavadi, Abhisek Dwivedy, Xing Wang, Fred Zhangzhi Peng, Pranam Chatterjee, Sherwood Yao

AptaBLE is a deep learning framework that predicts aptamer-protein binding and generates novel aptamers with high specificity and low Kd values.

bioRxiv · Feb 20, 2026 · PreprintBioinformatics

EVOFLOW-RNA: GENERATING AND REPRESENTING NON-CODING RNA WITH A LANGUAGE MODEL

Smit Patel, Fred Zhangzhi Peng, Keith Fraser, Adam D. Friedman, Pranam Chatterjee, Sherwood Yao

EvoFlow-RNA generates and represents non-coding RNA using a masked discrete diffusion model, outperforming existing models on RNA function tasks.

bioRxiv · Feb 25, 2025 · PreprintSynthetic Biology