APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice
Orla Bonnar, Kira Shaw, Silvia Anderle, Dori M. Grijseels, Devin Clarke, Laura Bell, Sarah L King, Catherine N. Hall
This study shows APOE4 mice have reduced vascular responsiveness and increased neuronal calcium signals in the visual cortex and hippocampus, suggesting APOE4 alters neurovascular function without causing severe deficits.
Journal of Cerebral Blood Flow & Metabolism · Jun 23, 2023Peer-reviewedNeuroscience