Orla Bonnar

Perivascular fibroblasts locally regulate the vasomotor dynamics of pial arterioles

This study identifies perivascular fibroblasts as regulators of cerebral vasomotion and cerebrospinal fluid movement through calcium dynamics and Gq signaling.

Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels

The paper shows that capillary injury and regression lead to sustained vasoconstriction in upstream vessels, reducing blood flow in both injured and uninjured regions of the microvascular network.

APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice

This study shows APOE4 mice have reduced vascular responsiveness and increased neuronal calcium signals in the visual cortex and hippocampus, suggesting APOE4 alters neurovascular function without causing severe deficits.

Hippocampus has lower oxygenation and weaker control of brain blood flow than cortex, due to microvascular differences

The paper shows the hippocampus has lower oxygenation and weaker blood flow control than cortex due to vascular differences, linking this to its vulnerability in neurological diseases.