Kira Shaw

This study examines vascular function and cognitive performance in mouse models of Alzheimer's disease, atherosclerosis, and their combination, finding hemodynamic deficits in atherosclerosis mice and no differences in amyloid or plaque burden in mixed disease models.

The paper examines locomotion-induced hemodynamic responses in different vascular compartments of the whisker barrel cortex in mice, finding an early HbT decrease in draining and meningeal veins.

This study shows APOE4 mice have reduced vascular responsiveness and increased neuronal calcium signals in the visual cortex and hippocampus, suggesting APOE4 alters neurovascular function without causing severe deficits.

This study shows that locomotion during awake imaging alters sensory-evoked haemodynamic responses in mice, emphasizing the need to monitor movement to avoid confounding results.

The paper evaluates three methods for identifying place cells in hippocampal data, finding that the Peak method is most reliable and robust, while different methods identify vastly different populations of place cells.

The paper shows the hippocampus has lower oxygenation and weaker blood flow control than cortex due to vascular differences, linking this to its vulnerability in neurological diseases.