Devin Clarke

This study shows APOE4 mice have reduced vascular responsiveness and increased neuronal calcium signals in the visual cortex and hippocampus, suggesting APOE4 alters neurovascular function without causing severe deficits.

The paper introduces an open-source pipeline for analyzing microglial morphology changes, using dimensionality reduction to generate an inflammation index, and demonstrates its application in a diet study with no significant effects found.

The paper shows the hippocampus has lower oxygenation and weaker blood flow control than cortex due to vascular differences, linking this to its vulnerability in neurological diseases.