Localized Chemogenetic Silencing of Inhibitory Neurons: A novel Mouse Model of Focal Cortical Seizures
Adi Miriam Goldenberg, Sarah Schmidt, Rea Mitelman, Dana Rubi Levy, Yonatan Katz, Ofer Yizhar, Heinz Beck, Ilan Lampl
This paper introduces a novel mouse model of focal cortical seizures using chemogenetic inhibition of GABAergic neurons, showing reliable induction of seizures with characteristics similar to human epilepsy.
bioRxiv · Nov 4, 2020 · PreprintNeuroscience