Cardiomyocyte prohibitin ablation reprograms cardiac metabolism revealing a pathogenic role for mTORC1 in dilated cardiomyopathy
Ran Huo, Sarah Torrence, Kaitlyn A. Berns, Rachel M Crawford, Amany A. Alowaisi, Jolonda C. Mahoney, Biyi Chen, Qian J Shi, Benjamin W. Darbro, Long‐Sheng Song, Ethan J. Anderson
This study shows that PHB complex ablation in cardiomyocytes leads to mTORC1 activation and metabolic reprogramming, causing dilated cardiomyopathy and mortality in mice.
bioRxiv · Sep 3, 2026 · PreprintCell Biology