Ethan J. Anderson

Cardiomyocyte prohibitin ablation reprograms cardiac metabolism revealing a pathogenic role for mTORC1 in dilated cardiomyopathy

This study shows that PHB complex ablation in cardiomyocytes leads to mTORC1 activation and metabolic reprogramming, causing dilated cardiomyopathy and mortality in mice.

Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contact Sites Precede Major (Mal)adaptations in Aging Skeletal Muscle and are Prevented by Exercise

This study identifies early aging-related changes in muscle MERC ultrastructure and proteome, which are reversed by exercise, suggesting potential therapeutic targets for sarcopenia.