ISL1 is necessary for auditory neuron development and contributes towards tonotopic organization
Iva Filová, Kateryna Pysanenko, Mitra Tavakoli, Simona Vochyánová, Martina Dvořáková, Romana Bohuslavová, Ondřej Smolík, Valeria Fabriciova, Petra Hrabalova, Sarka Benesova, Lukáš Valihrach, Jiri Cerny, Ebenezer N. Yamoah, Josef Syka, Bernd Fritzsch, Gabriela Pavlínková
This study shows that ISL1 is essential for auditory neuron development and tonotopic organization, but central plasticity cannot fully compensate for peripheral dysfunction.
Proceedings of the National Academy of Sciences · Sep 8, 2022Peer-reviewedNeuroscience