Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells
Robin M. Meyers, Jordan Bryan, James M. McFarland, Barbara A. Weir, Ann E. Sizemore, Han Xu, Neekesh V. Dharia, Philip G. Montgomery, Glenn S. Cowley, Sasha Pantel, Amy B. Goodale, Yenarae Lee, Levi D. Ali, Guozhi Jiang, Rakela Lubonja, , Aviad Tsherniak
The paper develops CERES, a computational method to correct copy-number effects in CRISPR-Cas9 essentiality screens, improving specificity in cancer cell line studies.
Nature Genetics · Oct 30, 2017Peer-reviewedGenomics