Author

Yenarae Lee

Broad InstituteORCID 0009-0002-3777-343XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander Wang YingiD· 1 shared Amy B. GoodaleiD· 1 shared Ann E. SizemoreiD· 1 shared Aviad TsherniakiD· 1 shared Barbara A. Weir· 1 shared Benjamin Jacob DrapkiniD· 1 shared Christopher R. VakociD· 1 shared Cigall KadochiD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alexander Wang YingORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer CellPeer-reviewedJul 18, 2024

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

Leslie Duplaquet, Kevin So, Alexander Wang Ying…·Matthew G. Oser

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

75 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsNature GeneticsPeer-reviewedOct 30, 2017

Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells

Robin M. Meyers, Jordan Bryan, James M. McFarland…·Aviad Tsherniak

The paper develops CERES, a computational method to correct copy-number effects in CRISPR-Cas9 essentiality screens, improving specificity in cancer cell line studies.

1,951 citationstop 1%

humanCRISPR screen

𝕏 PostBluesky