Author

Levi D. Ali

University of Massachusetts Chan Medical SchoolORCID 0000-0003-1148-7355Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Avijit MallickiD· 2 shared Cole M. HaynesiD· 2 shared Lihua Julie ZhuiD· 2 shared Rui LiiD· 2 shared Yunguang Du· 2 shared Amy B. GoodaleiD· 1 shared Andreas BergmanniD· 1 shared Ann E. SizemoreiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Avijit MallickORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 15, 2026

LONP-1 deficiency causes dysregulated protein synthesis within mitochondria that is restored by mitoribosomal mutations

Levi Ali, Avijit Mallick, Yunguang Du…·Cole M. Haynes

This study shows that LONP-1 deficiency disrupts mitochondrial protein synthesis and DNA replication in C. elegans, which is partially restored by mutations in mitochondrial ribosome proteins.

1 citation

C. elegansproteomics

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Developmental BiologybioRxivPreprintJan 22, 2025

AMP accumulation during mitochondrial stress induces transcription of cytosolic and mitochondrial protein synthesis components via NHR-180

Avijit Mallick, Theresa Raquel de Oliveira Ramalho, Yunguang Du…·Cole M. Haynes

The paper identifies NHR-180 as a regulator of mitochondrial function and protein synthesis that can restore mitochondrial function in atfs-1(null) worms and mammalian models.

1 citation

C. elegansmouse

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GenomicsNature GeneticsPeer-reviewedOct 30, 2017

Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells

Robin M. Meyers, Jordan Bryan, James M. McFarland…·Aviad Tsherniak

The paper develops CERES, a computational method to correct copy-number effects in CRISPR-Cas9 essentiality screens, improving specificity in cancer cell line studies.

1,951 citationstop 1%

humanCRISPR screen

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