RUNX1 is Expressed in a Subpopulation of Dermal Fibroblasts and Higher RUNX1 Levels are Associated with the Severity of Systemic Sclerosis
Rezvan Parvizi, Zhiyun Gong, Helen C. Jarnagin, Diana M. Toledo, Tamar R. Abel, Dillon Popovich, Madeline J Morrisson, Sasha Shenk, Monique Hinchcliff, Jonathan A. Garlick, Patricia Ann Pioli, Michael L. Whitfield
This study shows RUNX1 is expressed in SSc fibroblasts and higher levels correlate with fibrosis severity, with hypomethylation and inhibitor effects supporting its role in fibrosis.
bioRxiv · Apr 3, 2024 · PreprintGenomics