Author

Helen C. Jarnagin

Dartmouth CollegeORCID 0000-0002-7017-1409Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Michael L. WhitfieldiD· 3 shared Patricia Ann PioliiD· 3 shared Diana M. ToledoiD· 2 shared Dillon PopovichiD· 2 shared Jonathan A. GarlickiD· 2 shared Noelle N. KosarekiD· 2 shared Rajan BhandariiD· 2 shared Rezvan ParviziiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersGenomics

Michael L. WhitfieldORCID

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Author profile →

3 papers

Recent·Most cited

Anti-CD206 CAR T Cell Treatment Restores Fibrosis-Induced Loss of Dermal White Adipose Tissue

Chanhyuk Park, Asmaa O. Mohamed, Helen C. Jarnagin, Rajan Bhandari, Jason Gunn, Joana M. Murad-Mabaera, Noelle N. Kosarek, Fred Kolling, Owen Michael Wilkins, Yina H. Huang, Michael L. Whitfield, Patricia Ann Pioli

The paper demonstrates that anti-CD206 CAR T cells restore dermal white adipose tissue in systemic sclerosis by targeting CD206+ macrophages and reversing their effects on adipose-derived stem cells.

bioRxiv · Oct 16, 2025 · PreprintSynthetic Biology

RUNX1 is Expressed in a Subpopulation of Dermal Fibroblasts and Higher RUNX1 Levels are Associated with the Severity of Systemic Sclerosis

Rezvan Parvizi, Zhiyun Gong, Helen C. Jarnagin, Diana M. Toledo, Tamar R. Abel, Dillon Popovich, Madeline J Morrisson, Sasha Shenk, Monique Hinchcliff, Jonathan A. Garlick, Patricia Ann Pioli, Michael L. Whitfield

This study shows RUNX1 is expressed in SSc fibroblasts and higher levels correlate with fibrosis severity, with hypomethylation and inhibitor effects supporting its role in fibrosis.

bioRxiv · Apr 3, 2024 · PreprintGenomics

Single-cell epigenomic dysregulation of Systemic Sclerosis fibroblasts via CREB1/EGR1 axis in self-assembled human skin equivalents

Tamar R. Abel, Noelle N. Kosarek, Rezvan Parvizi, Helen C. Jarnagin, Gretel M. Torres, Rajan Bhandari, Mengqi Huang, Diana M. Toledo, Avi Smith, Dillon Popovich, Michael Mariani, Hee-Taek Yang, Tammara A. Wood, Jonathan A. Garlick, Patricia Ann Pioli, Michael L. Whitfield

The paper characterizes single-cell transcriptomic and epigenomic features of a 3D skin-like model of systemic sclerosis, identifying fibroblast subpopulations and their interactions with macrophages.

bioRxiv · Mar 22, 2024 · PreprintGenomics