Monique Hinchcliff

Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

SUN2 mediates epigenetic remodeling to drive mechanotransduction during skin fibrosis

This study identifies SUN2 as a mediator of nuclear mechanosensing in fibrosis, showing it drives chromatin remodeling and fibrotic gene expression in response to mechanical stiffness.

Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung disease

The paper identifies profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in SSc-ILD by analyzing BAL fluid and lung explants.

A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis

The paper identifies a nerve-fibroblast axis in lung fibrosis by integrating multiple experimental and computational approaches across species.

RUNX1 is Expressed in a Subpopulation of Dermal Fibroblasts and Higher RUNX1 Levels are Associated with the Severity of Systemic Sclerosis

This study shows RUNX1 is expressed in SSc fibroblasts and higher levels correlate with fibrosis severity, with hypomethylation and inhibitor effects supporting its role in fibrosis.

Gene Expression Meta-Analysis Reveals Aging and Cellular Senescence Signatures in Scleroderma-associated Interstitial Lung Disease

This study identifies aging and senescence signatures in SSc-ILD through gene expression analysis and telomere length measurement, linking them to disease pathology.

Three Distinct Transcriptional Profiles of Monocytes Correlate with Disease Activity in SSc Patients

This study identifies three monocyte transcriptional subgroups in SSc patients that correlate with disease activity, particularly lung function.

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis

Single-cell RNA-seq of lung tissue from transplant donors, fibrosis patients, and a living patient identifies cell type-specific disease-associated molecular pathways in pulmonary fibrosis.

Machine Learning of the Cardiac Phenome and Skin Transcriptome to Categorize Heart Disease in Systemic Sclerosis

This paper uses machine learning to classify heart disease subgroups in systemic sclerosis using echocardiographic and skin transcriptome data, identifying distinct phenotypes and associated molecular pathways.