Stage-specific CAR-mediated signaling generates naive-like, TCR-null CAR T cells from induced pluripotent stem cells
Sang Pil Yoo, Xuegang Yuan, Claire Engstrom, Patrick C. Chang, Suwen Li, Lindsay E. Lathrop, J. LaGosh, Satvik Saripalli, Anthony Azzun, Vincenzo Calvanese, Hanna K. A. Mikkola, Christopher Seet, Donald B. Kohn, Gay M. Crooks
This study generates TCR-null CAR T cells from iPSCs by controlling CAR signaling stages, resulting in naive-like cells with enhanced cytotoxicity.
bioRxiv · Nov 25, 2024 · PreprintBioengineering